Gilgit is located approximately 10 kilometres (6.2 mi) from the Karakoram Highway (KKH). The roadway is being upgraded as part of the China–Pakistan Economic Corridor. The KKH connects Gilgit to Chilas, Dasu, Besham, Mansehra, Abbottabad and Islamabad in the south. Gilgit is connected to Karimabad (Hunza) and Sust in the north, with further connections to the Chinese cities of Tashkurgan, Upal and Kashgar in Xinjiang. Gilgit is also linked to Chitral in the west, and Skardu to the east. The road to Skardu will be upgraded to a 4-lane road at a cost of $475 million.

Transport companies such as the Silk Route Transport Pvt, Masherbrum Transport Pvt and Northern Areas Transport Corporation (NATCO), offer passenger road transport between Islamabad, Gilgit, Sust, and Kashgar and Tashkurgan in China.

The Astore-Burzil Pass Road, linking Gilgit to Srinagar was closed in 1978.